null
SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
InChI Key InChIKey=LLWAEAQGDHLXKV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 259332
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
Affinity DataIC50: 2.00E+4nMAssay Description:Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
Affinity DataIC50: 6.31E+4nMAssay Description:Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of human EZH2 using core histone as substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
Affinity DataIC50: 6.31E+4nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair