null

SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=LLWAEAQGDHLXKV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 259332   

LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B5Z3TUS Patent
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 6.31E+4nMAssay Description:Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B5Z3TUS Patent
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 5.78E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP791QPubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of human EZH2 using core histone as substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM5D0BPubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 1.54E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80Z0PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 1.54E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D3059PubMed
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 6.31E+4nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent