null

SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(ccc3C)C(=O)Nc3cccc(c3)C(F)(F)F)cn2)cc1

InChI Key InChIKey=JZLAJYOZJKREKH-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26366   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 123nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 438nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed