null

SMILES Oc1cccc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1

InChI Key InChIKey=ZOCIUTOGAXVSTJ-MHZLTWQESA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 263669   

TargetEstrogen receptor(Homo sapiens (Human))
SANOFI

US Patent
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58PB1US Patent
TargetEstrogen receptor [D538G](Homo sapiens (Human))
SANOFI

US Patent
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58PB1US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
SANOFI

US Patent
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58PB1US Patent
TargetEstrogen receptor(Homo sapiens (Human))
SANOFI

US Patent
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Beta-2 adrenergic receptor antagonistic activity on guinea pig tracheal chainsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1FW0PubMed
TargetEstrogen receptor(Homo sapiens (Human))
SANOFI

US Patent
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Ability to inhibit the rat muscle adenylate kinase lII in competition with the AMP variedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1FW0PubMed
TargetEstrogen receptor(Homo sapiens (Human))
SANOFI

US Patent
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1FW0PubMed
TargetEstrogen receptor(Homo sapiens (Human))
SANOFI

US Patent
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1FW0PubMed