null

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cncnc1

InChI Key InChIKey=MDBBPOZQZACUGK-UHFFFAOYSA-N

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 26373   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 239nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 8.30E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 199nMAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56JJHPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20001WPPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 8.33E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20001WPPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20001WPPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20001WPPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20001WPPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20001WPPubMed