null

SMILES CN1CCC(CC1)Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1

InChI Key InChIKey=RCPGEVOBRRSEJB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26376   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM26376(4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 1.31E+3nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM26376(4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

LigandPNGBDBM26376(4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM26376(4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM26376(4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BCBPubMed