null

SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCO)CC3)cccc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 264194   

TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 7nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 2.53E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 3.00E+4nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 2.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 2.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 2.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK3 [811-1124](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent