null

SMILES COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F

InChI Key InChIKey=KRLOGMJQWZWUCD-JOCHJYFZSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 264233   

TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))TBA
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))TBA
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 322nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent
TargetTyrosine-protein kinase JAK3 [811-1124](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076P0PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076P0PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076P0PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 322nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076P0PubMed
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 322nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))TBA
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 322nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 322nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent