null
SMILES Cc1cccc2C(=O)NCCc12
InChI Key InChIKey=RLLZPXDJYADIEU-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 27682
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Pfizer Global R&D--La Jolla Laboratories
Curated by ChEMBL
Pfizer Global R&D--La Jolla Laboratories
Curated by ChEMBL
Affinity DataKi: 70nMAssay Description:Inhibition of human Poly (ADP-ribose) polymerase 1 enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP11(Homo sapiens)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Pfizer Global R&D--La Jolla Laboratories
Curated by ChEMBL
Pfizer Global R&D--La Jolla Laboratories
Curated by ChEMBL
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 9.77E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP11(Homo sapiens)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Pfizer Global R&D--La Jolla Laboratories
Curated by ChEMBL
Pfizer Global R&D--La Jolla Laboratories
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Pfizer Global R&D--La Jolla Laboratories
Curated by ChEMBL
Pfizer Global R&D--La Jolla Laboratories
Curated by ChEMBL
Affinity DataIC50: 160nMpH: 8.0 T: 2°CAssay Description:To assess the inhibitory activity of novel inhibitors, the PARP-1 enzyme assay was carried out in reaction mixture consisting of Escherichia coli str...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 9.77E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair