null

SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1

InChI Key InChIKey=DKKDSRACISNOLY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 282792   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20P122MUS Patent
TargetTGF-beta receptor type-1 [T204D](Homo sapiens (Human))
University of Wisconsin at Madison

LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85BFBUS Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RJ4NP9US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of TGFbetaR1 in TGFbeta-stimulated mink Mv1Lu cells assessed as reduction in SMAD nuclear translocation preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of TGFBR1 in TGFbeta-stimulated human NHLF cells assessed as reduction in SMAD2 nuclear translocationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of wild type His-tagged TGFBR2 kinase domain (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed