null
SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1
InChI Key InChIKey=DKKDSRACISNOLY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 282792
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Affinity DataIC50: 1.60nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Affinity DataIC50: 1.60nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Affinity DataIC50: 200nMAssay Description:Inhibition of TGFbetaR1 in TGFbeta-stimulated mink Mv1Lu cells assessed as reduction in SMAD nuclear translocation preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company
US Patent
Affinity DataIC50: 80nMAssay Description:Inhibition of TGFBR1 in TGFbeta-stimulated human NHLF cells assessed as reduction in SMAD2 nuclear translocationMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of wild type His-tagged TGFBR2 kinase domain (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair