null

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C12CCC(CC1)(CC2)C(O)=O

InChI Key InChIKey=XTLSAZFITBCMQC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 288560   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM288560(4-[8-amino-1-(4-{[4- (trifluoromethyl) pyridin-2- ...)copy SMILEScopy InChI
Affinity DataIC50: 0.130nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GF0WJCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM288560(4-[8-amino-1-(4-{[4- (trifluoromethyl) pyridin-2- ...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of 6-His-tagged recombinant full length BTK (unknown origin) expressed in baculovirus-transfected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20867K5PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM288560(4-[8-amino-1-(4-{[4- (trifluoromethyl) pyridin-2- ...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of BTK in human PBMCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20867K5PubMed