null

SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CC2(F)F)cc1

InChI Key InChIKey=PRDXEDQLSDAYKR-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 289671   

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart NeuroScience (Cayman) Ltd.

US Patent
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2514181US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart NeuroScience (Cayman) Ltd.

US Patent
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataIC50: 100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5J3QUS Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart NeuroScience (Cayman) Ltd.

US Patent
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ST7S6WUS Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart NeuroScience (Cayman) Ltd.

US Patent
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)copy SMILEScopy InChI
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed