null
SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CC2(F)F)cc1
InChI Key InChIKey=PRDXEDQLSDAYKR-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 289671
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart NeuroScience (Cayman) Ltd.
US Patent
Dart NeuroScience (Cayman) Ltd.
US Patent
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart NeuroScience (Cayman) Ltd.
US Patent
Dart NeuroScience (Cayman) Ltd.
US Patent
Affinity DataIC50: 100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart NeuroScience (Cayman) Ltd.
US Patent
Dart NeuroScience (Cayman) Ltd.
US Patent
Affinity DataIC50: 100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart NeuroScience (Cayman) Ltd.
US Patent
Dart NeuroScience (Cayman) Ltd.
US Patent
Affinity DataIC50: 11nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC
Curated by ChEMBL
Dart Neuroscience LLC
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC
Curated by ChEMBL
Dart Neuroscience LLC
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair