null

SMILES COc1cc(ccn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=KINCYOIHPUNFIT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291830   

LigandPNGBDBM291830(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MD7US Patent
LigandPNGBDBM291830(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)copy SMILEScopy InChI
Affinity DataIC50: 11.8nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MD7US Patent
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM291830(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0JNHUS Patent
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM291830(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0JNHUS Patent
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM291830(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)copy SMILEScopy InChI
Affinity DataIC50: 11.8nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0JNHUS Patent
LigandPNGBDBM291830(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MD7US Patent