null
SMILES Cc1cc(N)nc(C[C@H]2CNC[C@H]2NCCNCc2ccc(Cl)cc2)c1
InChI Key InChIKey=JDRSQGJWTVRNGM-QFBILLFUSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 29234
Affinity DataKi: 85nM ΔG°: -9.80kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 85nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University; The Regents of the University of California
US Patent
Northwestern University; The Regents of the University of California
US Patent
Affinity DataKi: 85nMAssay Description:Recombinant NOS isozymes over-expressed in E. coli were utilized. (Ji, H., et al., Discovery of highly potent and selective inhibitors of neuronal ni...More data for this Ligand-Target Pair
Affinity DataKi: 85nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain [D597N,M336V](Rattus norvegicus (rat))
University of California at Irvine
University of California at Irvine
Affinity DataKi: 1.20E+3nM ΔG°: -8.21kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Northwestern University; The Regents of the University of California
US Patent
Northwestern University; The Regents of the University of California
US Patent
Affinity DataKi: 8.95E+3nMAssay Description:Recombinant NOS isozymes over-expressed in E. coli were utilized. (Ji, H., et al., Discovery of highly potent and selective inhibitors of neuronal ni...More data for this Ligand-Target Pair
Affinity DataKi: 8.95E+3nMAssay Description:Inhibition of rat recombinant nNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 8.95E+3nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 8.50E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 8.50E+4nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Northwestern University; The Regents of the University of California
US Patent
Northwestern University; The Regents of the University of California
US Patent
Affinity DataKi: 8.52E+4nMAssay Description:Recombinant NOS isozymes over-expressed in E. coli were utilized. (Ji, H., et al., Discovery of highly potent and selective inhibitors of neuronal ni...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 8.52E+4nM ΔG°: -5.64kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
Affinity DataIC50: 740nMAssay Description:Inhibition of recombinant rat nNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of rat nNOS expressed in HEK293T cells preincubated for 30 mins prior A23187-induced activation measured after 6 hrs by Griess assayMore data for this Ligand-Target Pair