null

SMILES CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3cc[nH]c3n2)cc1F

InChI Key InChIKey=UOFYSRZSLXWIQB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 294480   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
ACEA BIOSCIENCES INC.

US Patent
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.399nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23R0VZ1US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
ACEA BIOSCIENCES INC.

US Patent
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.0911nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23R0VZ1US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
ACEA BIOSCIENCES INC.

US Patent
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 501nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23R0VZ1US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
ACEA BIOSCIENCES INC.

US Patent
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 3.27E+3nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23R0VZ1US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of wild type EGFR (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by mobility shift...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R62PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 279nMAssay Description:Inhibition of wild type EGFR L858R/T790M/C797S mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R62PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Inhibition of wild type EGFR Del E746/A750 mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R62PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.170nMAssay Description:Inhibition of wild type EGFR L858R mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R62PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R62PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMAssay Description:Inhibition of wild type EGFR C797S mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R62PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM294480(N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of wild type EGFR L858R/T790M mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 min...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R62PubMed