null

SMILES COc1cc(OCCN2CC(CF)C2)ccc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 299117   

TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM299117((6S,8R)-7-((l-fluorocyclopropyl)methyl)-6-(4-(2-(3...)copy SMILES
Affinity DataIC50: 10nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25B04KWUS Patent
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM299117((6S,8R)-7-((l-fluorocyclopropyl)methyl)-6-(4-(2-(3...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Displacement of fluormone ES2 green reagent from human GST-tagged ERalpha LBD (282 to 595 residues) expressed in baculovirus infected insect cells in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9GDBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM299117((6S,8R)-7-((l-fluorocyclopropyl)methyl)-6-(4-(2-(3...)copy SMILES
Affinity DataIC50: 0.126nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9GDBPubMed