null

SMILES Fc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=PPRQSCUSEPEPNV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 299181   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
KADMON CORPORATION, LLC

US Patent
LigandPNGBDBM299181(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7KR6US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM299181(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 2.93E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
KADMON CORPORATION, LLC

US Patent
LigandPNGBDBM299181(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM299181(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 2.93E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7KR6US Patent