null

SMILES CC1(C)Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)F)c1ccc(NC2CN(CCCF)C2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 301007   

TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM301007((S)-6-(7-(2,2- difluoroethyl)- 8,8-dimethyl- 6,7,8...)copy SMILES
Affinity DataIC50: 3.40nMAssay Description:The assay principle is that ER alpha-LBD (GST) is added to a fluorescent ligand to form a receptor/fluorophore complex. A terbium-labelled anti-GST a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P55QJ9US Patent
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM301007((S)-6-(7-(2,2- difluoroethyl)- 8,8-dimethyl- 6,7,8...)copy SMILES
Affinity DataIC50: 0.770nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P55QJ9US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM301007((S)-6-(7-(2,2- difluoroethyl)- 8,8-dimethyl- 6,7,8...)copy SMILES
Affinity DataIC50: 1.20E+4nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P55QJ9US Patent
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM301007((S)-6-(7-(2,2- difluoroethyl)- 8,8-dimethyl- 6,7,8...)copy SMILES
Affinity DataIC50: 3.20nMAssay Description:Displacement of fluormone ES2 green reagent from human GST-tagged ERalpha LBD (282 to 595 residues) expressed in baculovirus infected insect cells in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9GDBPubMed
TargetEstrogen receptor [307-554](Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM301007((S)-6-(7-(2,2- difluoroethyl)- 8,8-dimethyl- 6,7,8...)copy SMILES
Affinity DataIC50: 1.20E+4nMAssay Description:ER: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4SX5US Patent
TargetEstrogen receptor [307-554](Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM301007((S)-6-(7-(2,2- difluoroethyl)- 8,8-dimethyl- 6,7,8...)copy SMILES
Affinity DataIC50: 3.40nMAssay Description:The assay was performed as follows with all reagent additions carried out using the Beckman Coulter BioRAPTR FRD microfluidic workstation:1. Acoustic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8W8PUS Patent
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM301007((S)-6-(7-(2,2- difluoroethyl)- 8,8-dimethyl- 6,7,8...)copy SMILES
Affinity DataIC50: 0.794nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9GDBPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM301007((S)-6-(7-(2,2- difluoroethyl)- 8,8-dimethyl- 6,7,8...)copy SMILES
Affinity DataIC50: 3.40nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4SX5US Patent