null

SMILES CCN1C(=O)N(Cc2cnc3[nH]c(CN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F

InChI Key InChIKey=HCDMJFOHIXMBOV-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 301310   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 27nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PG1WPRPubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DR2XJ1US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N87CVPUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NC64C5US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736V5PUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736V5PUS Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using 7-ethoxyresorufin as substrate substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1867RPubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1867RPubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1867RPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1867RPubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using s-mephenytoin as substrate substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1867RPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1867RPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam or testosterone as substrate substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1867RPubMed
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:In vivo inhibition of FGFR2 in po dosed SCID mouse xenografted with human KATO III stomach cancer cell line administered as single dose and measured ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HH6PWNPubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HH6PWNPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 0.970nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765KCQPubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 35nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765KCQPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.14E+3nMMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 776nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765KCQPubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 6.90nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765KCQPubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 71nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44HQPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44HQPubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PG1WPRPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 201nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PG1WPRPubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair