null

SMILES Fc1ccccc1-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1

InChI Key InChIKey=XJJYJNMNYDNXNO-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 30192   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 126nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2794313PubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2794313PubMed
LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2794313PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 501nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44RQCPubMed
TargetRibosomal protein S6 kinase alpha-4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 5.80E+4nMAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2794313PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataEC50:  2.70E+3nMAssay Description:Inhibition of MK2 in LPS-stimulated human THP1 cells assessed as inhibition of Hsp27 phosphorylation pretreated 60 mins before LPS challenge measured...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataEC50:  372nMAssay Description:Inhibition of MK2 pretreated for 30 mins before fluorescein labeled substrate peptide addition measured after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2794313PubMed