null

SMILES CCN1CCN(CC1)C(=O)Cc1ccc(Nc2ncc(F)c(Nc3ccc(cc3)C(=O)Nc3ccccc3Cl)n2)cc1

InChI Key InChIKey=AKSIZPIFQAYJGF-UHFFFAOYSA-N

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 31837   

TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90706PubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90706PubMed
TargetAurora kinase C(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)copy SMILEScopy InChI
Affinity DataIC50: 432nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HZGPubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant GST-tagged N-terminal truncated human Aurora A (123 to 401 residues) expressed in Sf9 insect cell using tetra-LRRASLG pepti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2444SPubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)copy SMILEScopy InChI
Affinity DataIC50: 1.38E+3nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HZGPubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of Aurora A kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD4385PubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HZGPubMed