null

SMILES Cc1ccccc1Nc1cc2ccccc2c(=O)[nH]1

InChI Key InChIKey=FTWYTJPFSFTVCV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 32098   

TargetN-formyl peptide receptor 2(Homo sapiens (Human))
NMMLSC

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataKi: >4.03E+4nMAssay Description:University of New Mexico Assay Overview Assay Support: NIH 1R03MH076381-01 Assay for Formylpeptide Receptor Family Ligands PI: Bruce S. Edwards, Ph....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DF6PMFPCBioAssay
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
NMMLSC

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataKi: >4.37E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1R03MH076381-01 Assay for Formylpeptide Receptor Family Ligands PI: Bruce S. Edwards, Ph...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NZ862KPCBioAssay
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
NMMLSC

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 6.67E+4nMAssay Description:University of New Mexico Assay Overview Assay Support: NIH 1R03MH076381-01 Assay for Formylpeptide Receptor Family Ligands PI: Bruce S. Edwards, Ph....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DF6PMFPCBioAssay
TargetBcl-2-related protein A1(Mus musculus (Mouse))
Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K072NWPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 4.23E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT has been developed to assess actives that were identified in the Cdc25B HTS ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29K48M5PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 2.24E+3nMAssay Description:The Cdc25B Phosphatase probe assessment dose response reproducibility assay has been developed to re-confirm actives that were identified in the Cdc2...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25T3HWFPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 4.23E+3nMAssay Description:The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BG2MCPPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Catalase has been developed to assess actives that were identified in the Cdc25B HTS A...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X928QKPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT with Catalase has been developed to assess actives that were identified in t...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1J08PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Beta-Mercaptoethanol (BME) has been developed to assess actives that were identified i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0S8JPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Glutathione (GSH) has been developed to assess actives that were identified in the Cdc...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101KZPCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 1.21E+4nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DB806HPCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 8.75E+3nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K77GSPCBioAssay
TargetSUMO-conjugating enzyme UBC9(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 1.84E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V986G8PCBioAssay
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP0175PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis H37Rv)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataEC50:  1.12E+3nMAssay Description:Keywords: GFP, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, which interrupt the DnaB, RecA, a...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN14NRPCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis H37Rv)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataEC50:  616nMAssay Description:Keywords: GFP-RecA intein, protein splicing, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, whi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DR2SX9PCBioAssay
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
NMMLSC

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 6.67E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1R03MH076381-01 Assay for Formylpeptide Receptor Family Ligands PI: Bruce S. Edwards, Ph...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J67FB5PCBioAssay
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 3.38E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Q23XM6PCBioAssay
TargetBcl-2-related protein A1(Mus musculus (Mouse))
Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32098(3-(2-methylanilino)-2H-isoquinolin-1-one | 3-(o-to...)copy SMILEScopy InChI
Affinity DataIC50: 2.24E+4nMpH: 7.0 T: 2°CAssay Description:The aim is to identify chemical probes of Bfl-1 through a fluorescence polarization assay (FPA) using FITC-Bid BH3 peptide. 1) Dose-response curves c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N014W6PCBioAssay