BindingDB

null

SMILES COc1cc(c(OC)cc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12

InChI Key InChIKey=FWTDDBIMDSVPTR-AATRIKPKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 321424

Bromodomain-containing protein 9 [134-239](Homo sapiens (Human))
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

IC50: 4nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair

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Details
BindingDB Entry DOI: 10.7270/Q2125VRQUS Patent

Bromodomain and WD repeat-containing protein 1(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >5.00E+3nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 4(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

IC50: 2.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Bromodomain-containing protein 4(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

IC50: 2.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Chromatin remodeling regulator CECR2(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

IC50: 2.40E+3nMMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

IC50: 2.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 9(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

EC50: 13nMMore data for this Ligand-Target Pair

PDB KEGG
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ATPase family AAA domain-containing protein 2(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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ATPase family AAA domain-containing protein 2B(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain adjacent to zinc finger domain protein 2A(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain adjacent to zinc finger domain protein 2B(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Bromodomain-containing protein 1(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 2(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 2(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 2(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 3(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 3(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 3(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 4(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 4(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 4(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 4(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 7(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: 110nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Bromodomain-containing protein 8(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

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Bromodomain-containing protein 8(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

UniProtKB/SwissProt
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Bromodomain-containing protein 9(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: 2nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain testis-specific protein(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Bromodomain testis-specific protein(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
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Bromodomain testis-specific protein(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Peregrin(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Bromodomain and PHD finger-containing protein 3(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Chromatin remodeling regulator CECR2(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: 3.60E+3nMMore data for this Ligand-Target Pair

PDB KEGG
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CREB-binding protein(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Histone acetyltransferase p300(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB
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Nucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB KEGG
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Histone acetyltransferase KAT2A(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Protein polybromo-1(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

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Protein polybromo-1(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Histone acetyltransferase KAT2B(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Probable global transcription activator SNF2L2(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Transcription activator BRG1(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Transcription initiation factor TFIID subunit 1-like(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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Transcription intermediary factor 1-alpha(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >1.00E+4nMMore data for this Ligand-Target Pair

PDB KEGG
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E3 ubiquitin-protein ligase TRIM33(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

Kd: >5.00E+3nMMore data for this Ligand-Target Pair

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Bromodomain-containing protein 9(Homo sapiens (Human))TBA

PNG

BDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)copy SMILEScopy InChI

IC50: 5nMMore data for this Ligand-Target Pair

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Targets 29 ▿
- Bromodomain-containing protein 4 6
- Bromodomain-containing protein 3 3
- Bromodomain-containing protein 2 3
- Bromodomain testis-specific protein 3
- Bromodomain-containing protein 9 3
- Protein polybromo-1 2
- Transcription initiation factor TFIID subunit 1 2
- Bromodomain-containing protein 8 2
- Chromatin remodeling regulator CECR2 2
- ATPase family AAA domain-containing protein 2B 1
- Transcription initiation factor TFIID subunit 1-like 1
- Bromodomain and WD repeat-containing protein 1 1
- Bromodomain adjacent to zinc finger domain protein 2A 1
- Peregrin 1
- Bromodomain adjacent to zinc finger domain protein 2B 1
- Nucleosome-remodeling factor subunit BPTF 1
- Bromodomain and PHD finger-containing protein 3 1
- Bromodomain-containing protein 9 [134-239] 1
- Bromodomain-containing protein 1 1
- E3 ubiquitin-protein ligase TRIM33 1
- Histone acetyltransferase p300 1
- Transcription activator BRG1 1
- ATPase family AAA domain-containing protein 2 1
- CREB-binding protein 1
- Histone acetyltransferase KAT2B 1
- Histone acetyltransferase KAT2A 1
- Bromodomain-containing protein 7 1
- Transcription intermediary factor 1-alpha 1
- Probable global transcription activator SNF2L2 1
Publications 1 ▿
- US Patent US10183009 (2019) 1
Institutions 1 ▿
- [GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.] 1
Affinity: 2 to 2.0E+4 nM▿
- IC50 6
- Kd 39
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1