null

SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1

InChI Key InChIKey=MPLCIPBYGVWSAJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 322154   

TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataKi:  80nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataKi:  80nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataKi:  80nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataKi:  80nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataKi:  260nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataKi:  260nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataKi:  260nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataKi:  260nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 6.69E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.96E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.96E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 6.69E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.96E+3nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 6.69E+3nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.96E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 6.69E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent