null

SMILES COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(OCCN(C)C)n1

InChI Key InChIKey=KALDIQCXKRJULN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 322186   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322186(N-(6-(2-(dimethylamino)ethoxy)-2-(3-methoxyphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322186(N-(6-(2-(dimethylamino)ethoxy)-2-(3-methoxyphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322186(N-(6-(2-(dimethylamino)ethoxy)-2-(3-methoxyphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322186(N-(6-(2-(dimethylamino)ethoxy)-2-(3-methoxyphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322186(N-(6-(2-(dimethylamino)ethoxy)-2-(3-methoxyphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322186(N-(6-(2-(dimethylamino)ethoxy)-2-(3-methoxyphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent