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SMILES COCCN1CC[C@@H](NC(=O)c2cn(nn2)C(C)(C)C)c2ccc(cc2C1)-c1ccnc(Nc2cnn(C)c2)n1

InChI Key InChIKey=USXARGYHIWJRJZ-XMMPIXPASA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 324288   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
BIOGEN MA INC.

US Patent
LigandPNGBDBM324288((R)-1-(tert-butyl)-N-(2-(2-methoxyethyl)-8-(2-((1-...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69MP8US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
BIOGEN MA INC.

US Patent
LigandPNGBDBM324288((R)-1-(tert-butyl)-N-(2-(2-methoxyethyl)-8-(2-((1-...)copy SMILEScopy InChI
Affinity DataIC50: 505nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M681DUS Patent
TargetTyrosine-protein kinase BTK [14-552](Homo sapiens (Human))TBA
LigandPNGBDBM324288((R)-1-(tert-butyl)-N-(2-(2-methoxyethyl)-8-(2-((1-...)copy SMILEScopy InChI
Ligand InfoPC cidPC sid
In DepthDetails
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
BIOGEN MA INC.

US Patent
LigandPNGBDBM324288((R)-1-(tert-butyl)-N-(2-(2-methoxyethyl)-8-(2-((1-...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human BTK using fluorescein-labeled polyGAT peptide as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B641CPubMed
TargetEarly activation antigen CD69(Homo sapiens)TBA
LigandPNGBDBM324288((R)-1-(tert-butyl)-N-(2-(2-methoxyethyl)-8-(2-((1-...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of CD69 in human whole blood preincubated for 30 mins followed by anti-human IgD stimulation and measured after 18 to 22 hrs by flow cytom...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B641CPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
BIOGEN MA INC.

US Patent
LigandPNGBDBM324288((R)-1-(tert-butyl)-N-(2-(2-methoxyethyl)-8-(2-((1-...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N29US Patent