null

SMILES COc1cc(ccc1Nc1nc2ccc(cn2n1)-c1ccc(NC(=O)[C@H](C)c2ccc(F)cc2)cc1)C(=O)N1CC(F)C1

InChI Key InChIKey=JNKUNFBRYLQETD-LJQANCHMSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 329340   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent
LigandPNGBDBM329340((2R)—N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carb...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1N06US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent
LigandPNGBDBM329340((2R)—N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carb...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of MPS1 in human HeLa cells assessed as reduction in spindle assembly checkpoint incubated for 4 hrs by p-histone H3/Hoechst 33342 stainin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56VPPubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent
LigandPNGBDBM329340((2R)—N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carb...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56VPPubMed