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SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccc5cccnc5c4)cc3)cc2C(F)(F)F)CC1

InChI Key InChIKey=RVQLPYKLAJLXMV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 332703   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM332703(US10196378, Compound C06)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6VCPUS Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM332703(US10196378, Compound C06)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6VCPUS Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM332703(US10196378, Compound C06)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6VCPUS Patent
TargetTyrosine-protein kinase ABL1 [Y253F](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM332703(US10196378, Compound C06)copy SMILEScopy InChI
Affinity DataKi:  6.20nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6VCPUS Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM332703(US10196378, Compound C06)copy SMILEScopy InChI
Affinity DataKi:  1.20E+4nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6VCPUS Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM332703(US10196378, Compound C06)copy SMILEScopy InChI
Affinity DataIC50: 637nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24F1VP1PubMed