null

SMILES COc1nc2ccc(cc2c(Cl)c1C(=O)N1CCC(CC1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C

InChI Key InChIKey=DMKPTGTYCPYNJV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 339166   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM339166(US10201546, Example 83)copy SMILEScopy InChI
Affinity DataKd:  360nMAssay Description:ThermoFluor is a fluorescence based assay that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal stability (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47R8CUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM339166(US10201546, Example 83)copy SMILEScopy InChI
Affinity DataIC50: 386nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM339166(US10201546, Example 83)copy SMILEScopy InChI
Affinity DataKd:  357nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed