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SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3OCOc3cc2C1

InChI Key InChIKey=KTHLRNWGDXCNQL-GFCCVEGCSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 349365   

TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
COGNITION THERAPEUTICS, INC.

US Patent
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7JRGUS Patent
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
COGNITION THERAPEUTICS, INC.

US Patent
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6W8RUS Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))TBA
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H13641
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
COGNITION THERAPEUTICS, INC.

US Patent
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92DFNUS Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))TBA
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H13641
TargetSigma intracellular receptor 2(Homo sapiens (Human))
COGNITION THERAPEUTICS, INC.

US Patent
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6W8RUS Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
COGNITION THERAPEUTICS, INC.

US Patent
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92DFNUS Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
COGNITION THERAPEUTICS, INC.

US Patent
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7JRGUS Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
COGNITION THERAPEUTICS, INC.

US Patent
LigandPNGBDBM349365(US10207991, Ex. Cpd. No. 10 | US10611728, Example ...)copy SMILEScopy InChI
Affinity DataIC50: 4.10E+4nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6W8RUS Patent