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SMILES CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=UTVABCSMEKUFLJ-UHFFFAOYSA-N

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 35317   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nM EC50:  27nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K26PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K26PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K26PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.270nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K26PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5MFDPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5MFDPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5MFDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of Jak3 by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5MFDPubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K26PubMed