null

SMILES OC(CC1c2c(cccc2Cl)-c2cncn12)C1CCCCC1

InChI Key InChIKey=DQZNLVQWAVTPGD-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 370424   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Bayer HealthCare Pharmaceuticals Corporation

LigandPNGBDBM370424(2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyc...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26H4KQMUS Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Bayer HealthCare Pharmaceuticals Corporation

LigandPNGBDBM370424(2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyc...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26H4KQMUS Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Bayer HealthCare Pharmaceuticals Corporation

LigandPNGBDBM370424(2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyc...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
NewLink Genetics Corporation

Curated by ChEMBL
LigandPNGBDBM370424(2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyc...)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
NewLink Genetics Corporation

Curated by ChEMBL
LigandPNGBDBM370424(2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyc...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
NewLink Genetics Corporation

Curated by ChEMBL
LigandPNGBDBM370424(2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyc...)copy SMILEScopy InChI
Affinity DataIC50: 8.80E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Bayer HealthCare Pharmaceuticals Corporation

LigandPNGBDBM370424(2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyc...)copy SMILEScopy InChI
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed