null
SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cn[nH]c3)c2c1)C(C)C
InChI Key InChIKey=NPIPSFYAGMCQMP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 373519
Affinity DataKd: 17nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....More data for this Ligand-Target Pair
Affinity DataKd: 68nMAssay Description:FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 68nMAssay Description:FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
ASTEX THERAPEUTICS LTD
US Patent
ASTEX THERAPEUTICS LTD
US Patent
Affinity DataKd: 741nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 68nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 68nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
ASTEX THERAPEUTICS LTD
US Patent
ASTEX THERAPEUTICS LTD
US Patent
Affinity DataKd: 741nMAssay Description:KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...More data for this Ligand-Target Pair