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SMILES CN(C(=O)C=C)c1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c3CC(CCc3c12)C(C)(C)O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 377351   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Curacyte Chemistry GmbH

LigandPNGBDBM377351(US10266491, Example 19 | US10676434, Example 19 | ...)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112M3US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Curacyte Chemistry GmbH

LigandPNGBDBM377351(US10266491, Example 19 | US10676434, Example 19 | ...)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human full-length His-tagged BTK cytoplasmic domain expressed in baculovirus expression system using fluorescence-labelled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8B9CPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Curacyte Chemistry GmbH

LigandPNGBDBM377351(US10266491, Example 19 | US10676434, Example 19 | ...)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 ATP (20 and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HT2SG3US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Curacyte Chemistry GmbH

LigandPNGBDBM377351(US10266491, Example 19 | US10676434, Example 19 | ...)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN76Z8US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Curacyte Chemistry GmbH

LigandPNGBDBM377351(US10266491, Example 19 | US10676434, Example 19 | ...)copy SMILES
Affinity DataIC50: 15nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in intracellular calcium level incubated for 1 hr measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8B9CPubMed