null

SMILES CN1C[C@@H](c2cccc(c2)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c2cccc(c2)[C@@H]2CN(C)Cc3c(Cl)cc(Cl)cc23)c2cc(Cl)cc(Cl)c2C1

InChI Key InChIKey=DNHPDWGIXIMXSA-CXNSMIOJSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 381823   

TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 9.33nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 5.01nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent
TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent
TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 3.98nMAssay Description:The ability of compounds to inhibit Rat NHE3-mediated Na+-dependent H+ antiport after application and washout was measured using a modification of th...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent
TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 16nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB85X0PubMed
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 6.31nMAssay Description:The ability of compounds to inhibit Rat NHE3-mediated Na+-dependent H+ antiport after application and washout was measured using a modification of th...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent
TargetSodium-dependent phosphate transport protein 2B(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 3.16E+4nMAssay Description:The rate of phosphate (Pi) uptake into cells was measured using a modification of a literature method (see Mohrmann et al. Am. J. Phys. 250(3 pt 1):G...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 9.90E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB85X0PubMed
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM381823(CVD-0019453 | US10272079, Compound 002 | US1027207...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent