null

SMILES CN1C[C@@H](c2cccc(c2)S(=O)(=O)NCCOCCOCCNC(=O)Nc2ccc(NC(=O)NCCOCCOCCNS(=O)(=O)c3cccc(c3)[C@@H]3CN(C)Cc4c(Cl)cc(Cl)cc34)cc2)c2cc(Cl)cc(Cl)c2C1

InChI Key InChIKey=FZUDFYJYAGEEMC-ZYBCLOSLSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 381826   

TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
GlaxoSmithKline

LigandPNGBDBM381826(US10272079, Compound 003)copy SMILEScopy InChI
Affinity DataIC50: 2.51nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM381826(US10272079, Compound 003)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent
TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
GlaxoSmithKline

LigandPNGBDBM381826(US10272079, Compound 003)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB85X0PubMed
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM381826(US10272079, Compound 003)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB85X0PubMed
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM381826(US10272079, Compound 003)copy SMILEScopy InChI
Affinity DataIC50: 7.94nMAssay Description:The ability of compounds to inhibit Rat NHE3-mediated Na+-dependent H+ antiport after application and washout was measured using a modification of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MHHUS Patent