null

SMILES CC1(N)CCN(CC1)c1cnc(Sc2ccccc2Cl)c(N)n1

InChI Key InChIKey=HPRNFWNEHIBURH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 392330   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Cornell University

LigandPNGBDBM392330(US10301278, Example 2)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N87D37US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Cornell University

LigandPNGBDBM392330(US10301278, Example 2)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Allosteric inhibition of [IRSl_pY1172(dPEG8)pY1222] peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736VH5PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Cornell University

LigandPNGBDBM392330(US10301278, Example 2)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC14BBPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Cornell University

LigandPNGBDBM392330(US10301278, Example 2)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977NNPubMed
LigandPNGBDBM392330(US10301278, Example 2)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC14BBPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Cornell University

LigandPNGBDBM392330(US10301278, Example 2)copy SMILEScopy InChI
Affinity DataIC50: 98nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26977NNPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Cornell University

LigandPNGBDBM392330(US10301278, Example 2)copy SMILEScopy InChI
Affinity DataIC50: 251nMAssay Description:Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC14BBPubMed