null

SMILES C[C@H]1C[C@@H](N)C2(C1)CCN(CC2)c1nc(N)c(Sc2cccnc2C(F)(F)F)c(=O)n1C

InChI Key InChIKey=YASURKJIUFJZHZ-GXTWGEPZSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 395942   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395942(US10308660, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27S7R48US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395942(US10308660, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395942(US10308660, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation after 2 hrs by SureFire p-ERK assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395942(US10308660, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM395942(US10308660, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM395942(US10308660, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395942(US10308660, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation after 2 hrs by SureFire p-ERK assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed