null

SMILES C[C@@H]1CC2(CCN(CC2)c2nc(N)c(Sc3cccnc3C(F)(F)F)c(=O)n2C)[C@H](N)[C@H]1F

InChI Key InChIKey=UFFOHMITCZLLOC-OSAQELSMSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 395965   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395965(US10308660, Example 41)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27S7R48US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395965(US10308660, Example 41)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM395965(US10308660, Example 41)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM395965(US10308660, Example 41)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395965(US10308660, Example 41)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395965(US10308660, Example 41)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation after 2 hrs by SureFire p-ERK assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM395965(US10308660, Example 41)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation after 2 hrs by SureFire p-ERK assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K4FQKPubMed