null

SMILES NCc1cccc(c1)-n1nc(cc1C(=O)Nc1cc(ccc1F)C(N)(CCC1CC1)c1cccc(c1)C#N)C(F)(F)F

InChI Key InChIKey=ZBDDMFBNDOEVJT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 416996   

TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q218GUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates. In these experiments, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22J6FXHUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FT8Q7SUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi:  25.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XW4PXV
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi:  25.1nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZC862HUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HM5CNFUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R78HM5US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi: >100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J1078D
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi: >100nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FT8Q7SUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi: >100nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HM5CNFUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi: >100nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates. In these experiments, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22J6FXHUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi: >100nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26Q218GUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi: >100nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZC862HUS Patent
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataKi: >100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XW4PXV
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB572SPubMed
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB572SPubMed
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB572SPubMed
TargetPlasma kallikrein(Homo sapiens (Human))
BioCryst Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM416996((+)-N-(5-(1-amino-1-(3-cyanophenyl)-3-cyclopropylp...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB572SPubMed