null

SMILES COc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3F)c2cc1OC

InChI Key InChIKey=AZGVCABJHURYHG-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4457   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4457(4-(4-Chloro-2-fluorophenylamino)-6,7-dimethoxyquin...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z31WVPPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM4457(4-(4-Chloro-2-fluorophenylamino)-6,7-dimethoxyquin...)copy SMILEScopy InChI
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5GXNPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM4457(4-(4-Chloro-2-fluorophenylamino)-6,7-dimethoxyquin...)copy SMILEScopy InChI
Affinity DataIC50: 1.39E+4nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22V2D9MPubMed