null

SMILES CC(C)C1CCC(CC1)C(=O)Nc1ccncc1

InChI Key InChIKey=ZOJWMHJRZRKSRN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 448554   

TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)copy SMILEScopy InChI
Affinity DataIC50: 1.13E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)copy SMILEScopy InChI
Affinity DataIC50: 1.63E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9N5NUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)copy SMILEScopy InChI
Affinity DataIC50: 1.13E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)copy SMILEScopy InChI
Affinity DataIC50: 1.63E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent