null

SMILES CS(=O)(=O)c1ccc(Nc2nn(cc2C(N)=O)[C@@H]2CCCC[C@H]2C#N)cc1

InChI Key InChIKey=YIKWKYDCXBWSII-BLLLJJGKSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 47170   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM47170(US8962608, 42-1 | US8962608, 42-4)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101W0US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM47170(US8962608, 42-1 | US8962608, 42-4)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101W0US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM47170(US8962608, 42-1 | US8962608, 42-4)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101W0US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM47170(US8962608, 42-1 | US8962608, 42-4)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101W0US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM47170(US8962608, 42-1 | US8962608, 42-4)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101W0US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM47170(US8962608, 42-1 | US8962608, 42-4)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101W0US Patent