null

SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CC[C@H](O)C2=O)nc1C

InChI Key InChIKey=UCWFGTHMIDAVDE-KXBFYZLASA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489283   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489283(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3S)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489283(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3S)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 249nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489283(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3S)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
LigandPNGBDBM489283(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3S)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent