null

SMILES OC(c1ccc(NC(=O)C2N(Cc3cc(ccc23)S(=O)(=O)CC2CC2)C=O)cc1)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=TUMWNEOCLIEIOQ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 493606   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM493606(US10988445, Example 202)copy SMILEScopy InChI
Affinity DataIC50: 31.6nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BG2S35US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM493606(US10988445, Example 202)copy SMILEScopy InChI
Affinity DataIC50: 7.94nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BG2S35US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM493606(US10988445, Example 202)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
LigandPNGBDBM493606(US10988445, Example 202)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM493606(US10988445, Example 202)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at human RORC2 assessed as inhibition of SRC1-derived coactivator peptide by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed