null

SMILES CC(=O)N1Cc2cc(ccc2C1C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)NC1CC1

InChI Key InChIKey=MGOPCYIZHYONRL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 493697   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM493697(US10988445, Example 500)copy SMILEScopy InChI
Affinity DataIC50: 50.1nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BG2S35US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM493697(US10988445, Example 500)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BG2S35US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM493697(US10988445, Example 500)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
LigandPNGBDBM493697(US10988445, Example 500)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM493697(US10988445, Example 500)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at human RORC2 assessed as inhibition of SRC1-derived coactivator peptide by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed