null

SMILES [H][C@]12C[C@]([H])(C=C1)[C@]1([H])C(=O)N(C(=O)[C@]21[H])c1ccc(cc1)C(=O)Nc1cccc2cccnc12

InChI Key InChIKey=ZGSXEXBYLJIOGF-ALFLXDJESA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50007583   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Mus musculus)
Universit£ degli Studi di Perugia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XT9PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Mus musculus)
Universit£ degli Studi di Perugia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health& Science University

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 135nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health& Science University

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 135nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 131nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1PK7PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 1.88E+4nMAssay Description:Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 1.88E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1PK7PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 1.88E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1PK7PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 131nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health& Science University

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 1.88E+4nMAssay Description:Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Health& Science University

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)copy SMILEScopy InChI
Affinity DataIC50: 56nMMore data for this Ligand-Target Pair