null
SMILES CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F
InChI Key InChIKey=LMMJFBMMJUMSJS-UHFFFAOYSA-N
PDB links: 3 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50010462
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of N...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of ...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Celgene Quanticel Research, Inc.
US Patent
Celgene Quanticel Research, Inc.
US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Celgene Quanticel Research, Inc.
US Patent
Celgene Quanticel Research, Inc.
US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Celgene Quanticel Research, Inc.
US Patent
Celgene Quanticel Research, Inc.
US Patent
Affinity DataIC50: 160nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))TBA
In DepthDetails
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL