null
SMILES COc1ccc(cc1)-c1nc(O)c2ccccc2n1
InChI Key InChIKey=HETSSARHFAGODR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50019166
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]DPCPX from Sprague-Dawley rat whole brain membrane A1AR by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]NECA from Sprague-Dawley rat striatal membrane A2A adenosine receptor by scintillation counting analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University of Bath
Curated by ChEMBL
University of Bath
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of TNKS-1 (unknown origin) using histone as substrate incubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of PARP-1 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Compound was tested for TXA2 receptor antagonism by measuring its ability to inhibit contraction of rat aorta induced by the stable TXA2 agonist U-46...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University of Bath
Curated by ChEMBL
University of Bath
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected Sf9 cells assessed...More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant human full-length Myc/His-tagged Parp-1 expressed in baculovirus infected Sf21 insect cells assessed as reduction in auto-P...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Merck Healthcare KGaA
Curated by ChEMBL
Merck Healthcare KGaA
Curated by ChEMBL
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of tankyrase 1/2 in human DLD1 cells assessed as increase in axin2 accumulation incubated for 24 hrs by luminex based bead assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare KGaA
Curated by ChEMBL
Merck Healthcare KGaA
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected Sf9 cells assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 minsMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University of Bath
Curated by ChEMBL
University of Bath
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare KGaA
Curated by ChEMBL
Merck Healthcare KGaA
Curated by ChEMBL
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University of Bath
Curated by ChEMBL
University of Bath
Curated by ChEMBL
In DepthDetails
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare KGaA
Curated by ChEMBL
Merck Healthcare KGaA
Curated by ChEMBL
Affinity DataIC50: 611nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrat...More data for this Ligand-Target Pair