null

SMILES OB(O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1

InChI Key InChIKey=XSBZZZGVAIXJLD-YUMQZZPRSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50050521   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:In vitro test for inhibitory activity against human dipeptidyl peptidase IV.More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3J7ZUS Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 770nMAssay Description:Compound was tested in vitro for inhibition of Dipeptidylpeptidase IIMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z95K5PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:In vitro for inhibition of Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 8.48E+4nMAssay Description:Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 4.71E+5nMAssay Description:Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5BJCPubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+4nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB77SRUS Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB77SRUS Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 5.40E+4nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB77SRUS Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+4nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB77SRUS Patent
TargetHomeobox protein PKNOX1(Human)TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB77SRUS Patent
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+7nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB77SRUS Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3J7ZUS Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3J7ZUS Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3J7ZUS Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3J7ZUS Patent
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3J7ZUS Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMpH: 2.0Assay Description:The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is eq...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50050521((2-Dihydroxyborane-pyrrolidin-1-yl)-pyrrolidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+4nMpH: 8.0Assay Description:The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is eq...More data for this Ligand-Target Pair