null

SMILES OC1=C(Sc2ccccc2Cl)C(=O)CC(C1)c1c(Cl)cccc1Cl

InChI Key InChIKey=WOBNNXBIQRYYDO-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50052254   

TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 870nMAssay Description:LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+3nMAssay Description:LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95800PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445P46PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445P46PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445P46PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445P46PubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4XV9PubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged MDH-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445P46PubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHB by UV endpoint assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445P46PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataKd:  1.80E+3nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHA by SPR assayMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assayMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 870nMAssay Description:Inhibition of human LDH-A by biochemical assayMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 870nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50052254(2',6'-dichloro-4-((2-chlorophenyl)thio)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged MDH-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445P46PubMed